Synfacts 2019; 15(07): 0817
DOI: 10.1055/s-0039-1689776
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Photoredox-Catalyzed Decarboxylative Alkynylation of Peptides

Hisashi Yamamoto
An Wu
Garreau M, Le Vaillant F, Waser J. * Ecole Polytechnique Fédérale de Lausanne, Switzerland
C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation.

Angew. Chem. Int. Ed. 2019;
58: 8182-8186
Further Information

Publication History

Publication Date:
17 June 2019 (online)



This paper provides a decarboxylative strategy for the alkynylation of the C-terminus of peptides, starting from free carboxylic acids. C-Terminal selectivity can be achieved in the presence of carboxylic acid side chains, and a broad range of functional groups are tolerated in the ­reaction system.



The authors have developed a metal-free decarboxylative alkynylation of the C-terminus of peptides. The reaction proceeds rapidly and cleanly and might be useful for modifying peptides.