Abstract
Objective Whether melatonin receptor 1B (MTNR1B) variants are implicated in gestational diabetes mellitus (GDM) remains unclear.
Therefore, we performed this meta-analysis to obtain a more conclusive result on associations
between MTNR1B variants and GDM.
Study Design Literature research was performed in PubMed, Web of Science, Embase, and China National
Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were
calculated.
Results A total of 17 studies were eligible for analyses. Pooled overall analyses showed
that rs1387153 (dominant model: p = 0.0002, OR = 0.78, 95% CI: 0.68–0.89; recessive model: p < 0.0001, OR = 1.46, 95% CI: 1.24–1.73; allele model: p < 0.0001, OR = 0.78, 95% CI: 0.72–0.84), rs4753426 (recessive model: p = 0.01, OR = 1.75, 95% CI: 1.14–2.68; allele model: p = 0.01, OR = 0.69, 95% CI: 0.51–0.93), and rs10830963 (dominant model: p < 0.0001, OR = 0.72, 95% CI: 0.65–0.78; recessive model: p < 0.0001, OR = 1.56, 95% CI: 1.40–1.74; allele model: p < 0.0001, OR = 0.73, 95% CI: 0.69–0.78) variants were all significantly associated
with the susceptibility to GDM. Further subgroup analyses by ethnicity of participants
yielded similar positive results.
Conclusion Our findings indicated that MTNR1B rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of
GDM.
Keywords
melatonin receptor 1B - genetic variants - gestational diabetes mellitus - meta-analysis
