The Effect of Intrapartum Vancomycin on Vaginal Group B Streptococcus Colony Counts

Abstract

Objective To define the temporal relationship between intrapartum intravenous vancomycin administration and vaginal group B streptococcus (GBS) colony counts.

Study Design Prospective cohort study conducted from October 2014 to February 2017. Women with antenatal cultures demonstrating GBS colonization and a plan for vancomycin administration were eligible. Intrapartum vaginal cultures were collected prior to the first vancomycin infusion and every 2 hours up to five collections or delivery. Results were analyzed in two groups: participants with at least one positive intrapartum culture and those without any positive intrapartum cultures.

Results A total of 63 women were enrolled. Among consented women, a total of 8 were excluded and 3 participants' cultures were never plated, thus leaving a total of 52 women for analysis. The degree of vaginal GBS colonization varied between subjects and was not normally distributed. Colony counts dropped rapidly from hour 0 to hour 2 (median: 6.0 × 10⁸ vs. 1.0 × 10⁸, p < 0.01). Standardizing hour 0 colony counts to 100%, the percent decline in colony counts from hour 0 to hour 2 was significant (p = 0.03), and at each subsequent time point fell further.

Conclusion GBS vaginal colony counts fall rapidly after intrapartum vancomycin administration.

Keywords

GBS prophylaxis - intrapartum antibiotics - intrapartum antibiotic prophylaxis - intrapartum vancomycin - vaginal GBS colony counts - vancomycin

Condensation

Similar to intrapartum penicillin and intrapartum clindamycin, intrapartum intravenous vancomycin decreases vaginal group B streptococcus colony counts.

Note

Findings from this study were presented at the 44th Annual Meeting of the Infectious Disease Society of Obstetrics and Gynecology, Park City, UT, August 10–12, 2017.

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