Near-Infrared Imaging Using Intravenous Indocyanine Green at a Conventional Dose to Locate Pulmonary Metastases: A Pilot Study

Abstract

Intravenous indocyanine green (ICG) has been reported to localize intra-abdominal metastatic lesions in several clinical trials. Our pilot study aimed to investigate the feasibility and safety of ICG fluorescence localization in pulmonary metastasectomy using a near-infrared fluorescence thoracoscope. Each patient received intravenous 0.25 or 0.5 mg/kg of ICG. The maximum diameter of the tumor on computed tomography ranged from 0.5 to 3.5 (median: 1.15) cm. Intravenous ICG injection localized pulmonary metastases in a portion (3 patients) of the enrolled patients. Our preliminary results provided us with important information to modify the study protocol.

Keywords

pulmonary metastasis - clinical trial - near-infrared

• References

• 1 Casiraghi M, De Pas T, Maisonneuve P. , et al. A 10-year single-center experience on 708 lung metastasectomies: the evidence of the “international registry of lung metastases”. J Thorac Oncol 2011; 6 (08) 1373-1378
• 2 Chen F, Sakai H, Miyahara R, Bando T, Okubo K, Date H. Repeat resection of pulmonary metastasis is beneficial for patients with colorectal carcinoma. World J Surg 2010; 34 (10) 2373-2378
• 3 Hamaji M, Chen F, Miyamoto E. , et al. Surgical and non-surgical management of repeat pulmonary metastasis from sarcoma following first pulmonary metastasectomy. Surg Today 2016; 46 (11) 1296-1300
• 4 UMIN Clinical Trials Registry. Available at: http://www.umin.ac.jp/ctr/index.htm . Accessed January 18, 2018
• 5 Keating J, Newton A, Venegas O. , et al. Near-infrared intraoperative molecular imaging can locate metastases to the lung. Ann Thorac Surg 2017; 103 (02) 390-398
• 6 ClinicalTrials.com. Available at: http://www.clinicaltrials.com . Accessed January 18, 2018
• 7 Liberale G, Vankerckhove S, Caldon MG. , et al; Group R&D for the Clinical Application of Fluorescence Imaging of the Jules Bordetʼs Institute. Fluorescence imaging after indocyanine green injection for detection of peritoneal metastases in patients undergoing cytoreductive surgery for peritoneal carcinomatosis from colorectal cancer: a pilot study. Ann Surg 2016; 264 (06) 1110-1115
• 8 Liberale G, Vankerckhove S, Galdon MG, Donckier V, Larsimont D, Bourgeois P. Fluorescence imaging after intraoperative intravenous injection of indocyanine green for detection of lymph node metastases in colorectal cancer. Eur J Surg Oncol 2015; 41 (09) 1256-1260
• 9 Takeda AH, Watanabe Y, Nagata T. , et al. Detection of alternative subpleural lymph flow pathways using indocyanine green fluorescence. Surg Today 2018; 48 (06) 640-648