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Thromb Haemost 1999; 81(03): 367-372
DOI: 10.1055/s-0037-1614479
Review Article
Schattauer GmbH

A Randomised, Controlled Study of the Effects of Aerobic Exercise and Dietary Fish on Coagulation and Fibrinolytic Factors in Type 2 Diabetics

David W. Dunstan
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
,
Trevor A. Mori
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
,
Ian B. Puddey
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
,
Lawrie J. Beilin
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
,
Valerie Burke
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
,
Alan R. Morton
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
,
Kim G. Stanton
1   From the Departments of Medicine and Human Movement, University of Western Australia, West Australian Heart Research Institute, Department of Diabetes and Endocrinology, Royal Perth Hospital, Australia
› Author AffiliationsThis study was financially supported by grants from the West Australian Health Promotion Foundation (Healthway), the Royal Perth Hospital Medical Research Foundation and a program grant from the National Health and Medical Research Council of Australia.
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Publication History

Publication Date:
09 December 2017 (online)

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Summary

Type 2 diabetes is associated with disturbances in coagulation and fibrinolysis. Prospective studies show that increased tissue plasminogen activator (tPA) antigen increases the risk of cardiovascular mortality. The present study examined the hypothesis that combining a regime of moderate aerobic exercise with one daily fish meal as part of a low-fat diet (30% total energy) would improve coagulation and fibrinolytic factors in dyslipidaemic type 2 diabetic patients. In a randomised, controlled, 8-week trial, 55 sedentary type 2 diabetic subjects with serum triglycerides >1.8 mmol/l and/or HDL-C <1.0 mmol/l were randomly assigned to a low-fat diet (30% daily energy intake) with or without one fish meal daily (3.6 g ω3 fatty acids/day) and further randomized to a moderate (55-65% VO2max) or light (heart rate <100 bpm) exercise program. Plasma levels of fibrinogen, coagulation factor VIIc, tPA and plasminogen activator inhibitor (PAI-1) antigen were measured before and after intervention. In the 49 subjects who completed the study, the fish diet alone, moderate exercise alone and the combination of fish and moderate exercise all led to significant reductions in tPA antigen concentrations (-2.1 ng/ml, p = 0.02, -1.9 ng/ml, p = 0.03, -2.0 ng/ml, p = 0.01, respectively) compared to controls. In multivariate regression, changes in fasting blood glucose (positively) and erythrocyte ω3 fatty acid composition (inversely) were independent predictors of the change in tPA antigen. The fish diet alone contributed to a significant rise in coagulation factor VIIc compared to controls (4.9%, p = 0.02), which was prevented by moderate exercise. No significant effects on PAI-1 antigen and fibrinogen were seen. In view of recent epidemiological findings, the reduction in tPA antigen with both fish and moderate exercise in these dyslipidaemic type 2 diabetic patients could reflect a reduced thrombotic potential and decreased cardiovascular risk. Furthermore, a small, albeit significant, increase in coagulation factor VIIc associated with fish can be prevented by a concomitant programme of moderate exercise.

 

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