Abstract
Derangements of the blood coagulation-fibrinolytic system are thought to be associated
with the development of cardiovascular disease. Previous studies have identified the
alterations in patients with advanced atherosclerosis, however, studies on subjects
without apparent cardiovascular complications are scarce. To evaluate the potential
risk of thrombosis, we examined the serum lipid levels and fibrinolytic parameters
in 54 subjects of different types of primary hyperlipoproteinemia (HL) and 18 normolipidemic
controls. Plasma tissue-type plasminogen activator (t-PA) and plasminogen activator
inhibitor-1 (PAI-1) antigen levels were significantly higher in type IV HL than in
the controls. Serum triglyceride concentrations were correlated with t-PA (r = 0.537,
p < 0.01) and PAI-1 (r = 0.249, p < 0.05) antigen levels, while serum cholesterol
levels did not. The current study demonstrated that hypertriglyceridemia, but not
hypercholesterolemia, is associated with the alterations of fibrinolytic system.
Key words
Fibrinolysis - Plasma Tissue-Type Plasminogen Activator Antigen - Plasma Plasminogen
Activator Inhibitor-1 Antigen - Hypertriglyceridemia
