Efficient Synthesis of Optically Active Neolignans Ligraminol D and E

Ganesh S. Ghotekar; M. Mujahid; M. Muthukrishnan

doi:10.1055/s-0037-1611919

Synthesis, Table of Contents

Synthesis 2019; 51(22): 4291-4295
DOI: 10.1055/s-0037-1611919

paper

Efficient Synthesis of Optically Active Neolignans Ligraminol D and E

Ganesh S. Ghotekar

^aDivision of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India Email: m.muthukrishnan@ncl.res.in

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

,

M. Mujahid

^cP. G. Department of Chemistry, Shri Shivaji College of Arts, Commerce & Science, Akola 444001, India

,

M. Muthukrishnan∗

^aDivision of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India Email: m.muthukrishnan@ncl.res.in

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

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Abstract

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Abstract

Efficient syntheses of optically active neolignans ligraminol D and E were achieved in four simple steps starting from easily available chiral benzyl glycidyl ethers. The products were obtained in good overall yields and high enantioselectivities. The protocol might also be useful in the synthesis of other ligraminols or related neolignans.

Key words

ligraminol - epoxide - lignan - benzyl glycidyl ether - Mitsunobu

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References

References

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