Synthesis 2019; 51(20): 3847-3858
DOI: 10.1055/s-0037-1611900
paper
© Georg Thieme Verlag Stuttgart · New York

Facile Synthesis of Dispiroheterocycles through One-Pot [3+2] Cycloaddition, and Their Antiviral Activity

Min Zhang
a   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. of China   Email: zhangmin@ujs.edu.cn   Email: zhucycn@gmail.com
b   State Key Laboratory of the Discovery and Development of Novel Pesticide (Shenyang Sinochem Agrochemicals R&D Co. Ltd), Shenyang 110021, P. R. of China
,
Wenbo Yang
a   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. of China   Email: zhangmin@ujs.edu.cn   Email: zhucycn@gmail.com
,
Kailu Li
a   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. of China   Email: zhangmin@ujs.edu.cn   Email: zhucycn@gmail.com
,
Ke Sun
b   State Key Laboratory of the Discovery and Development of Novel Pesticide (Shenyang Sinochem Agrochemicals R&D Co. Ltd), Shenyang 110021, P. R. of China
,
Jianfen Ding
a   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. of China   Email: zhangmin@ujs.edu.cn   Email: zhucycn@gmail.com
,
Liuqing Yang
a   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. of China   Email: zhangmin@ujs.edu.cn   Email: zhucycn@gmail.com
,
Chunyin Zhu
a   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. of China   Email: zhangmin@ujs.edu.cn   Email: zhucycn@gmail.com
› Author Affiliations
This study was financially supported by the National Natural Science Foundation of China (No. 31501686), the State Key Laboratory of the Discovery and Development of Novel Pesticide (Shenyang Sinochem Agrochemicals R&D Co. Ltd) (No. 2017NYRD01), the Qinglan Project of Jiangsu Province of China and the Jiangsu University Foundation (No. 13JDG059).
Further Information

Publication History

Received: 07 March 2019

Accepted after revision: 02 July 2019

Publication Date:
30 July 2019 (online)


Abstract

A facile synthesis of novel dispiroheterocycles has been developed through one-pot [3+2] cycloaddition between isatins, amino acids, and aurones. Thirty different dispiroheterocycles were synthesized eusing this method which features mild conditions, convenient operation, and high efficacy. Evaluation of the bioactivity of these dispiroheterocyclic products revealed antiviral activity against tobacco mosaic virus (TMV).

Supporting Information

 
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