Fe-Catalyzed Bisphosphorylation of Amino-2-en-1-ones with Trialkyl Phosphites

Shengmei Guo; Kun Jie; Ling Huang; Zhebin Zhang; Yufeng Wang; Zhengjiang Fu; Hu Cai

doi:10.1055/s-0037-1611803

Synlett, Inhaltsverzeichnis

Synlett 2019; 30(09): 1090-1094
DOI: 10.1055/s-0037-1611803

letter

Fe-Catalyzed Bisphosphorylation of Amino-2-en-1-ones with Trialkyl Phosphites

Shengmei Guo

,

Kun Jie

,

Ling Huang

,

Zhebin Zhang

,

Yufeng Wang

,

Zhengjiang Fu

,

Hu Cai*

Department of Chemistry, Nanchang University, No. 999, Xuefu Rd. Nanchang, 330031, P. R. of China eMail: Caihu@ncu.edu.cn

› Institutsangaben

Abstract

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Abstract

A facile bisphosphorylation of amino-2-en-1-ones with trialkyl phosphites mediated by iron is developed. The reaction is considered to go through two Michael addition progresses. A variety of amino-2-en-1-ones are bisphosphorylated in high yields with functional group tolerance. In addition, the protocol of introduction of two different phosphates into one molecule is successful through a cascade reaction.

Key words

iron - bisphosphorylation - amino-2-en-1-ones - cascade reaction.

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Referenzen

References and Note

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11 2-[(Diethylamino)methyl]-1-phenylprop-2-en-1-one (1a) Ketone 1 (1 mmol) was mixed with silica gel (2.0 g) in a mortar. Then formaldehyde (0.18 g, 3 mmol, 37% in H₂O) and dialkylamine (2 mmol) were added and mixed. The mixture was placed into a flask with a cap and stirred for 5–7 h at room temperature. Then diethyl ether (20 mL) was added. After filtration and the removal of the solvent at the reduced pressure, the product was isolated. Further purification of the crude reaction mixture on silica gel column gave the pure product.
12 General Procedure for 3a To a 50 mL Schlenk tube with a stir bar added allylamine derivatives 1a (81.9 mg, 0.3 mmol), triethyl phosphite (149.5 mg, 3 equiv), Fe(NO₃)₃·9H₂O (20 mol%), and DCE (2 mL), the mixture was stirred at 100 °C for 5 h and monitored by TLC. The solution was then evaporated under vacuum. The crude reaction mixture was purified by column chromatography on silica gel (pure EtOAc) to get product 3a.¹H NMR (400 MHz, CDCl₃): δ = 8.12 (d, J = 7.4 Hz, 2 H), 7.58 (t, J = 7.1 Hz, 1 H), 7.51 (t, J = 7.4 Hz, 2 H), 4.34 (ddd, J = 20.5, 13.9, 6.6 Hz, 1 H), 4.13–3.91 (m, 8 H), 2.44–2.32 (m, 2 H), 2.14–2.01 (m, 2 H), 1.24 (t, J = 7.0 Hz, 6 H), 1.14 (t, J = 7.0 Hz, 6 H) ppm.¹³C NMR (101 MHz, CDCl₃): δ = 199.77, 199.68, 199.59, 135.05, 133.61, 128.92, 128.88, 77.32, 77.00, 76.68, 62.56, 62.49, 62.35, 62.29, 34.46, 34.43, 34.41, 28.95, 28.85, 27.53, 27.43, 16.24, 16.18, 16.10, 16.03 ppm.³¹P NMR (243 MHz, CDCl₃): δ = 28.09 ppm. HRMS: m/z calcd for C₁₈H₃₁O₇P₂ [M + H]⁺: 421.1540; found: 421.1541.
13 General Procedure for 5a To a 50 mL Schlenk tube with a stir bar added allylamine derivatives 1a (81.9 mg, 0.3 mmol), diethyl phosphite (82.8 mg, 2 equiv), and DCE (2 mL), the mixture was stirred at 100 °C for 8 h. Then, trialkyl phosphite (1.5 equiv), Fe(NO₃)₃·9H₂O (20 mol%), and DCE (2 mL) were added. The mixture was stirred at 100 °C for 5 h and monitored by TLC. The solution was then evaporated under vacuum. The crude reaction mixture was purified by column chromatography on silica gel (pure EtOAc) to get the product. ¹H NMR (400 MHz, CDCl₃): δ = 8.01 (d, J = 7.4 Hz, 2 H), 7.58 (t, J = 7.3 Hz, 1 H), 7.48 (t, J = 7.6 Hz, 2 H), 4.21–4.06 (m, 1 H), 4.00 (p, J = 7.3 Hz, 4 H), 3.62 (d, J = 10.9 Hz, 6 H), 2.43–2.23 (m, 2 H), 2.17–2.02 (m, 2 H), 1.24–1.16 (m, 6 H) ppm.¹³C NMR (101 MHz, CDCl₃): δ = 199.91 (s), 135.59 (s), 133.51 (s), 128.73 (d, J = 13.8 Hz), 61.91 (t, J = 6.9 Hz), 52.39 (t, J = 6.5 Hz), 34.96 (t, J = 3.3 Hz), 29.65 (d, J = 12.6 Hz), 28.35 (dd, J = 20.7, 11.8 Hz), 27.05 (d, J = 11.1 Hz), 16.27 (t, J = 5.8 Hz) ppm. ³¹P NMR (243 MHz, CDCl₃): δ = 30.78, 27.87 ppm. HRMS: m/z calcd for C₁₆H₂₇O₇P₂ [M + H]⁺: 393.1227; found: 393.1227.

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