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Synthesis 2019; 51(16): 3077-3084
DOI: 10.1055/s-0037-1611799
DOI: 10.1055/s-0037-1611799
paper
Palladium-Catalyzed C(sp2)−H Olefination/Annulation Cascades of Aryl Carboxamides Assisted by N,S-Bidentate Auxiliary
We thank the National Natural Science Foundation of China (No. 21302144) for financial support.
Further Information
Publication History
Received: 27 January 2019
Accepted after revision: 25 March 2019
Publication Date:
25 April 2019 (online)
Abstract
A palladium(II)-catalyzed olefination/annulation of aryl carboxamides, assisted by an N, S-bidentate auxiliary, with methyl acrylate is described. Various carboxamides with a number of functional groups were compatible with this reaction to afford, regioselectively and in moderate yield, (E)-3-methyleneisoindolin-1-one derivatives bearing an alkyl(aryl)thio group.
Key words
palladium(II)-catalyzed - olefination - annulation - carboxamides - N,S-bidentate directing group - isoindolesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611799.
- Supporting Information
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For selected examples of metal-catalyzed C–H activations, see: