Synthesis, Inhaltsverzeichnis Synthesis 2019; 51(10): 2122-2127DOI: 10.1055/s-0037-1611719 paper © Georg Thieme Verlag Stuttgart · New YorkIsocyanide Purification: C-2 Silica Cleans Up a Dirty Little Secret Allen Chao a Department of Chemistry, Drexel University, 32 South, 32nd St., Philadelphia, PA 19104, USA eMail: fleming@drexel.edu , Embarek Alwedi b Merck, 90 E. Scott Ave., Rahway, NJ 07065, USA , Fraser F. Fleming * a Department of Chemistry, Drexel University, 32 South, 32nd St., Philadelphia, PA 19104, USA eMail: fleming@drexel.edu› InstitutsangabenArtikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract EtSiCl3-treated silica gel, ‘C-2 silica,’ proved exceptionally effective for purifying isocyanides that are otherwise irreversibly adsorbed during silica gel chromatography. Purification of a prototypical isocyanide on several chromatographic matrices provided valuable insight into the requirements for purifying silica-sensitive isocyanides. EtSiCl3-modified silica proved optimal as the solid phase, providing up to 90% recovery of pure isocyanides that otherwise fail to elute during silica gel purification. Key words Key wordsisocyanide - isonitrile - purification - silica - sensitive Volltext Referenzen References 1 Chakrabarty S, Choudhary S, Doshi A, Liu FQ, Mohan R, Ravindra MP, Shah D, Yang X, Fleming FF. Adv. Synth. Catal. 2014; 356: 2135 2 Walborsky HM. Periasamy MP. Recent Advances in Isocyanide Chemistry in The Chemistry of Functional Groups, Supplement C. Patai S. Rappoport Z. John Wiley and Sons; 835-883 , Chap. 20, 1983 3 Isocyanide Chemistry: Applications in Synthesis and Material Science. Nenajdenko VG. Wiley-VCH; Weinheim: 2012 4a Zarganes-Tazitzikas T, Dömling A. Org. Chem. Front. 2014; 1: 834 4b Rostamnia S. RSC Adv. 2015; 5: 97044 5 Determined by searching SciFinder the terms isocyanide and isocyanide for years 2010 onwards. 6 Ugi I. Isocyanide Chemistry . 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