Microwave-Assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino Alcohols

Xiang Li; Ning Chen; Jiaxi Xu

doi:10.1055/s-0037-1611536

Synthesis, Table of Contents

Synthesis 2019; 51(17): 3336-3344
DOI: 10.1055/s-0037-1611536

paper

Microwave-Assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino Alcohols

Xiang Li

,

Ning Chen *

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. of China Email: chenning@mail.buct.edu.cn Email: jxxu@mail.buct.edu.cn

,

Jiaxi Xu*

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. of China Email: chenning@mail.buct.edu.cn Email: jxxu@mail.buct.edu.cn

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Abstract

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Abstract

A microwave (MW)-assisted three-component coupling of amino alcohols, aldehydes, and alkynes is developed under catalysis by CuCl. Compared with thermal conditions, MW irradiation greatly increases the reaction efficiency. The reactions of various primary N-alkyl/arylamino alcohols, aliphatic/aromatic aldehydes, and alkynes are systematically investigated, affording the desired products in moderate to good yields. Notably, acetylene is also an effective reactant under the current MW-assisted conditions.

Key words

microwave-assisted - three-component reactions - propargylamino alcohols - Cu catalysis - A³-coupling

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