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Synthesis 2019; 51(13): 2713-2719
DOI: 10.1055/s-0037-1611533
DOI: 10.1055/s-0037-1611533
special topic
Enantioselective Synthesis of 2-Substituted Pyrrolidines via Intramolecular Reductive Amination
Financial support from the National Natural Science Foundation of China (21772155, 21402155 and 21602172) is gratefully acknowledged.Further Information
Publication History
Received: 19.03.2109
Accepted after revision: 12 April 2019
Publication Date:
07 May 2019 (online)
Published as part of the Special Topic Amination Reactions in Organic Synthesis
Abstract
Catalyzed by the complex generated in situ from iridium and the chiral ferrocene ligand, tert-butyl (4-oxo-4-arylbutyl)carbamate substrates were deprotected and then reductively cyclised to form 2-substituted arylpyrrolidines in a one-pot manner, in which the intramolecular reductive amination was the key step. A range of chiral 2-substituted arylpyrrolidines were synthesised in up to 98% yield and 92% ee.
Key words
asymmetric catalysis - intramolecular reductive amination - iridium - chiral ligand - arylpyrrolidineSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611533.
- Supporting Information
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