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DOI: 10.1055/s-0037-1611527
Intermolecular Reactions of Pyridyl Radicals with Olefins via Photoredox Catalysis
Autor*innen
Financial support for this work was provided by startup funds from Emory University and the National Institutes of Health (GM129495).
Publikationsverlauf
Received: 01. März 2019
Accepted after revision: 04. April 2019
Publikationsdatum:
24. April 2019 (online)
Abstract
Pyridines are valuable motifs in a number of bioactive and functional molecules. The chemoselective functionalization of these structures from stable and widely available starting materials is a meaningful goal. We have demonstrated selective formation of pyridyl radicals at any position (2-, 3-, 4-pyridyl), through the action of a reducing photoredox catalyst. These radicals readily engage alkenes to deliver high-value products. Alteration of the reaction medium has enabled the use of a diverse range of alkene subtypes in a highly divergent and chemoselective manner.
1 Introduction
2 Minisci-Type Pyridine Alkylation
3 An Alternate Approach – Reductive Radical Formation
4 Conjugate Addition of Pyridyl Radicals
5 Radical Hydroarylation of Neutral and Rich Olefins
6 Solvent-Based Chemoselectivity
7 Summary and Outlook
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