Synfacts 2019; 15(01): 0095
DOI: 10.1055/s-0037-1611428
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Stereoselective Synthesis of α-Aryl Amino Acids

Hisashi Yamamoto
Wataru Muramatsu
Leonard D, Ward JW, Clayden J. * University of Bristol, UK
Asymmetric α-Arylation of Amino Acids.

Nature 2018;
562: 105-109
Further Information

Publication History

Publication Date:
14 December 2018 (online)



Quaternary amino acids play an important role as modifiers of peptide conformation and bioactivity. The authors describe an α-arylation of enantiopure amino acid precursors to form quaternary centers.



This KHMDS-mediated α-arylation of enantiopure amino acid precursors proceeds smoothly to provide quaternary amino acids in high yields and without significant loss of stereochemical integrity.