Enantioselective Palladium-Catalyzed Dearomative Heck Reaction
Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction.
J. Am. Chem. Soc. 2018;
14 December 2018 (online)
The authors report an enantioselective palladium-catalyzed dearomative Heck process, which affords a variety of spiroheterocycles and benzo-fused heterocycles in high yields and enantioselectivities.
Various sets of conditions were developed, depending on the heterocyclic scaffold employed. A remarkable number of examples (88) were demonstrated, and the synthetic utility of the products was displayed by a series of derivatizations.