Synlett 2019; 30(01): 114-118
DOI: 10.1055/s-0037-1611362
letter
© Georg Thieme Verlag Stuttgart · New York

DDQ-Mediated Cross-Dehydrogenative-Coupling Reaction of Secondary Amines with Dialkyl Phosphonates

Authors

  • Ming-Xing Cheng*

    College of Pharmacy, Henan University of Chinese Medicine, No. 156 Jinshui East Road, Zhengzhou 450046, P. R. of China   Email: chengmx2018@hactcm.edu.cn
  • Jing-Wei Lei

  • Cai-Xia Xie


Financial support from the Project of Science and Technology of Henan Province (No. 162102310448).
Further Information

Publication History

Received: 29 September 2018

Accepted after revision: 09 November 2018

Publication Date:
30 November 2018 (online)


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Abstract

This work reports a DDQ-mediated cross-dehydrogenative-coupling reaction of secondary amines with dialkyl phosphonates under mild conditions. This reaction proceeds efficiently without involving visible light or transition-metal catalysis. This new approach provides efficient access to biologically important α-aminophosphonates.

Supporting Information