A new and efficient approach for the N-arylation of 8-aminoquinoline amides with diaryliodonium
salts has been developed. This chelation-assisted selective C–N cross-coupling reaction
gave the desired N-arylated 8-aminoquinoline in moderate to good yields. In contrast
to previous reports, no additional ligands and bases are used in this transformation.
In addition, the anion of the diaryliodonium salt plays an important role in the success
of the process.
Key words
copper catalysis - diaryliodonium salts - arylation - aminoquinolines - chelation
assistance - quinolinylarylamides