Niobium Pentachloride Mediated (Hetero)aromatic Aldehyde Friedel–Crafts Hydroxyalkylation with Arenes: An Efficient Strategy to Synthesize Triarylmethanes

Shirley M. M. Rodrigues; Daniel Previdi; Giovanni S. Baviera; Alexandre A. Matias; Paulo M. Donate

doi:10.1055/s-0037-1610727

Synthesis, Table of Contents

Synthesis 2019; 51(23): 4498-4506
DOI: 10.1055/s-0037-1610727

paper

Niobium Pentachloride Mediated (Hetero)aromatic Aldehyde Friedel–Crafts Hydroxyalkylation with Arenes: An Efficient Strategy to Synthesize Triarylmethanes

Shirley M. M. Rodrigues∗

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901, Ribeirão Preto, Brazil Email: shirleymma@yahoo.com.br

,

Daniel Previdi

,

Giovanni S. Baviera

,

Alexandre A. Matias

,

Paulo M. Donate

› Author Affiliations

Abstract

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This paper is dedicated to Professor Mauricio Gomes Constantino on the occasion of his 75^th birthday.

Abstract

Niobium pentachloride is an efficient and useful Lewis acid to conduct Friedel–Crafts hydroxyalkylation between arenes and (hetero)aromatic aldehydes, to generate triarylmethanes. This practical methodology offers several advantages, such as short reaction time, mild experimental conditions, and excellent yields.

Keywords

triarylmethanes - niobium pentachloride - Friedel–Crafts hydroxyalkylation - carbocations - (hetero)aromatic aldehydes

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References

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