A catalyst-free three-component synthesis of α-aryl- and α-alkenylglycine derivatives
starting from glyoxylic acid, sulfonamides, and aryl- or alkenylboronic acids is described.
This operationally simple method tolerates a broad range of functional groups and
enables the generation of a wide array of α-amino acids. Sulfonamides were utilized
as amine component in the classic Petasis reaction for the first time.
Key words
multicomponent reaction - Petasis-borono Mannich reaction - sulfonamides - amino acids
- catalyst free
