Synlett 2018; 29(15): 1933-1936
DOI: 10.1055/s-0037-1610149
synpacts
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Astellatol: A Three-Decade Synthetic Puzzle

Nan Zhao
Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China   Email: xuj@sustc.edu.cn
,
Shengling Xie
Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China   Email: xuj@sustc.edu.cn
,
Hengjun Huang
Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China   Email: xuj@sustc.edu.cn
,
Jing Xu  *
Department of Chemistry, and Shenzhen Grubbs Institute, Southern University of Science and Technology, No. 1088 Xueyuan Ave. Nanshan, Shenzhen, Guangdong, 518055, P. R. of China   Email: xuj@sustc.edu.cn
› Author Affiliations
Financial support from NSFC (21402082, 21772082), SZDRC Discipline Construction Program, and SZSTI (JCYJ20170817110515599, KQJSCX20170728154233200) is gratefully acknowledged.
Further Information

Publication History

Received: 03 April 2018

Accepted after revision: 17 April 2018

Publication Date:
28 May 2018 (online)


Abstract

Here we briefly discuss and review our journey to achieve the first, enantiospecific total synthesis of a rare, complex sesterterpenoid, astellatol.

1 Introduction

2 Model Study of Reductive Radical Cyclization

3 Total Synthesis of Astellatol

4 Conclusion

 
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