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Synthesis 2018; 50(13): 2516-2522
DOI: 10.1055/s-0037-1609717
DOI: 10.1055/s-0037-1609717
paper
First Total Synthesis of 7-Isovaleryloxy-8-methoxygirinimbine
Authors
Further Information
Publication History
Received: 27 February 2018
Accepted after revision: 26 March 2018
Publication Date:
19 April 2018 (online)
Abstract
We describe the first total synthesis of the pyrano[3,2-a]carbazole alkaloid 7-isovaleryloxy-8-methoxygirinimbine, using a palladium(II)-catalyzed double C–H-bond activation for construction of the carbazole framework and a phenylboronic acid catalyzed annulation of the pyran ring as key steps.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609717.
- Supporting Information (PDF)
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Pyrayafoline C, isolation:
Synthesis:
Murrayamine-J, isolation:
Synthesis:
Murrayamine-A (mukoenine-C), isolation:
Synthesis:
Koenigine, isolation:
Synthesis: