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Synlett 2018; 29(13): 1669-1674
DOI: 10.1055/s-0037-1609716
DOI: 10.1055/s-0037-1609716
synpacts
Directing Methylene Oxidation towards Azaheterocycles by Transition-Metal and Organic Catalysis
Authors
Financial support was provided by MIT start-up funds, where the experimental work described in reference 14 was performed.
Further Information
Publication History
Received: 07 March 2018
Accepted after revision: 29 March 2018
Publication Date:
02 May 2018 (online)
Abstract
A combination of transition-metal and organic catalysis has been used to deliver a system that can selectively oxidize benzylic methylene groups adjacent to azaheterocycles in preference to other positions that are typically more reactive. Here, we provide more background and context that describes what inspired our approach to catalyst development.
1 Introduction
2 Site-Selective Methylene Oxidation
3 Literature Inspiration for Design Plan
4 Combined Ligand/Metal/HAT Catalyst Effects
5 Perspectives for Future Work
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