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Synthesis 2018; 50(21): 4325-4335
DOI: 10.1055/s-0037-1609560
DOI: 10.1055/s-0037-1609560
paper
A Highly Efficient Method for the Bromination of Alkenes, Alkynes and Ketones Using Dimethyl Sulfoxide and Oxalyl Bromide
Financial support from the National Key Research and Development Program (2016YFD0400801), the Beijing Postdoctoral Research Foundation (2017-22-011) and the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions (CIT&TCD20140306) is gratefully acknowledged.Further Information
Publication History
Received: 28 April 2018
Accepted after revision: 21 June 2018
Publication Date:
08 August 2018 (online)
Abstract
The pairing of DMSO and oxalyl bromide is reported as a highly efficient brominating reagent for various alkenes, alkynes and ketones. This bromination approach demonstrates remarkable advantages, such as mild conditions, low cost, short reaction times, provides excellent yields in most cases and represents a very attractive alternative for the preparation of dibromides and α-bromoketones.
Key words
bromination - dimethyl sulfoxide - oxalyl bromide - alkenes - alkynes - ketones - bromodimethylsulfonium saltSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609560.
- Supporting Information
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