We describe herein the palladium-catalyzed aminocarbonylation of nitrogen-containing
heterocycles with aniline derivatives using molybdenum hexacarbonyl as a CO solid
source, expanding the scope of the limited examples. This method is compatible with
a variety of substitutions on the aniline moiety. The simple reaction conditions include
easily available Pd(dppf)Cl2 catalyst, DBU as base in DMF at 120 °C for 3 hours in sealed tube thereby leading
to the isolation of 21 compounds with yields ranging from 18 to 82%. We also show
that double aminocarbonylation reactions are possible in satisfactory yields regarding
both coupling partners.
Key words
heterocycles - nitrogen - aromatic amines - amide - carbonylation - palladium - catalysis
