Abstract
Objective This study aims to determine the risk factors and outcome of persistent pulmonary
hypertension of the newborn (PPHN)-associated acute kidney injury (AKI).
Study Design Infants diagnosed with PPHN at Hat Yai Hospital from January 2012 to December 2016
were retrospectively reviewed.
Results Of the 109 included PPHN infants, 28.4% (31/109) died, and AKI was found in 28.4%
following neonatal KDIGO classification. Of the 31, 19 who died (61.3%) reached stage
1, 3 (9.7%) reached stage 2, and 9 (29.0%) reached stage 3. AKI (all stages combined)
was significantly associated with increased mortality with an odds ratio (OR) of 8.71
(95% confidence interval [CI], 3.37–22.49). Multivariate logistic regression analysis
indicated that male gender (adjusted OR = 8.56; 95% CI = 0.84–85.09) and urine output
of < 1 mL/kg/h in 12 hours of admission (adjusted OR = 15.57; 95% CI = 2.58–93.98)
were the main factors associated with an increased risk for AKI, while birth by cesarean
delivery was associated with reduced risk of AKI (adjusted OR = 0.10; 95% CI = 0.16–0.68).
Conclusion The incidence of AKI in PPHN was high in this study, and this complication was also
significantly associated with higher mortality. In PPHN neonates, AKI should be especially
closely monitored in males and infants who have a urine output of < 1 mL/kg/h in the
first 12 hours of admission.
Keywords
persistent pulmonary hypertension of the newborn - neonatal mortality - acute kidney
injury - acute renal failure - newborn infant
