Neurodevelopment and Growth of a Cohort of Very Low Birth Weight Preterm Infants Compared to Full-Term Infants in Brazil

Abstract

Objective The objective of this study was to investigate the neurodevelopment and growth of very low birth weight (BW) preterm infants, at 8 and 18 months corrected age (CA), compared with full term in Brazil.

Methods Prospective cohort study including 83 preterm infants with BW ≤ 1,500 g and gestational age ≤ 32 weeks, and 52 full-term control infants. Preterm infants free from significant sensory and motor disability, and from congenital anomalies were included. Alberta infant motor scale (AIMS) and Brunet–Lèzini scale (BLS) were used to evaluate the neurodevelopment at 8 and 18 months. Anthropometric measurements were collected to evaluate the growth in both age groups.

Results At 8 months CA, preterm infants scored significantly lower in total AIMS score (p = 0.001). At 18 months, they scored significantly lower on the stand subscale from AIMS (p = 0.040) and exhibited poor psychomotor development in the BLS (p = 0.006). The nutritional status showed significant differences between the groups, in both age groups (p < 0.001). There were positive correlations between nutritional status and AIMS (r = 0.420; p < 0.001) and BLS (r = 0.456; p < 0.001) at 8 months, and between head circumference and BLS (r = 0.235; p < 0.05) at 8 months and AIMS (r = 0.258; p < 0.05) at 18 months.

Conclusion Very low BW preterm infants at 8 and 18 months CA showed significant differences in the neurodevelopment and growth pattern when compared with their full-term peers.

Keywords

preterm infants - very low birth weight infants - growth - neurodevelopment

• References

• 1 Behrman RE, Butler AS. , eds. Preterm Birth: Causes, Consequences, and Prevention. Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Institute of Medicine. Washington: National Academies Press; 2007
• 2 Rebage V, Ruiz-Escusol S, Fernández-Vallejo M. , et al. Neurological newborn in our center and follow-up [in Spanish]. Rev Neurol 2008; 47 (Suppl. 01) S1-S13
• 3 van Haastert IC, de Vries LS, Helders PJ, Jongmans MJ. Early gross motor development of preterm infants according to the Alberta infant motor scale. J Pediatr 2006; 149 (05) 617-622
• 4 Pin TW, Eldridge B, Galea MP. Motor trajectories from 4 to 18 months corrected age in infants born at less than 30 weeks of gestation. Early Hum Dev 2010; 86 (09) 573-580
• 5 Kayenne Martins Roberto Formiga C, Linhares MBM. Motor development curve from 0 to 12 months in infants born preterm. Acta Paediatr 2011; 100 (03) 379-384
• 6 Syrengelas D, Kalampoki V, Kleisiouni P. , et al. Alberta infant motor scale (AIMS) performance of Greek preterm infants: comparisons with full-term infants of the same nationality and impact of prematurity-related morbidity factors. Phys Ther 2016; 96 (07) 1102-1108
• 7 Rugolo LM. [Growth and developmental outcomes of the extremely preterm infant]. J Pediatr (Rio J) 2005; 81 (Suppl. 01) S101-S110
• 8 Gäddlin PO. Follow-up studies of very low birthweight children in Sweden. Acta Paediatr 2011; 100 (07) 940-949
• 9 Committee on fetus and newborn. Hospital discharge of the high-risk neonate. American Academy of Pediatrics. Pediatrics (United States) 2008; 122: 1119-1126
• 10 Soleimani F, Vameghi R, Hemmati S, Hemmati S, Salman-Roghani R. Perinatal and neonatal risk factors for neurodevelopmental outcome in infants in Karaj. Arch Iran Med 2009; 12 (02) 135-139
• 11 Pin TW, Darrer T, Eldridge B, Gálea MP. Motor development from 4 to 8 months corrected age in infants born at or less than 29 weeks' gestation. Dev Med Child Neurol 2009; 51 (09) 739-745
• 12 Darrah J, Bartlett D, Maguire TO, Avison WR, Lacaze-Masmonteil T. Have infant gross motor abilities changed in 20 years? A re-evaluation of the Alberta infant motor scale normative values. Dev Med Child Neurol 2014; 56 (09) 877-881
• 13 Valentini NC, Saccani R. Brazilian validation of the Alberta infant motor scale. Phys Ther 2012; 92 (03) 440-447
• 14 Saccani R, Valentini NC. Reference curves for the Brazilian alberta infant motor scale: percentiles for clinical description and follow-up over time. J Pediatr (Rio J) 2012; 88 (01) 40-47
• 15 Charkaluk ML, Truffert P, Fily A, Ancel PY, Pierrat V. ; Epipage study group. Neurodevelopment of children born very preterm and free of severe disabilities: the Nord-Pas de Calais Epipage cohort study. Acta Paediatr 2010; 99 (05) 684-689
• 16 Manacero S, Nunes ML. Evaluation of motor performance of preterm newborns during the first months of life using the Alberta infant motor scale (AIMS). J Pediatr (Rio J) 2008; 84 (01) 53-59
• 17 Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard score, expanded to include extremely premature infants. J Pediatr 1991; 119 (03) 417-423
• 18 Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol 1996; 87 (02) 163-168
• 19 Richardson DK, Corcoran JD, Escobar GJ, Lee SK. SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores. J Pediatr 2001; 138 (01) 92-100
• 20 Stoll BJ, Hansen N, Fanaroff AA. , et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110 (2 Pt 1): 285-291
• 21 Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92 (04) 529-534
• 22 Silveira RC, Procianoy RS, Dill JC, da Costa CS. Periventricular leukomalacia in very low birth weight preterm neonates with high risk for neonatal sepsis. J Pediatr (Rio J) 2008; 84 (03) 211-216
• 23 Kaempf JW, Campbell B, Sklar RS. , et al. Implementing potentially better practices to improve neonatal outcomes after reducing postnatal dexamethasone use in infants born between 501 and 1250 grams. Pediatrics 2003; 111 (4 Pt 2): e534-e541
• 24 Piper MC, Darrah J. Motor Assessment of the Developing Infant. Philadelphia, PA: W.B. Saunders Co; 1994
• 25 Valentini NC, Saccani R. Escala Motora Infantil de Alberta: validação para uma população gaúcha. Rev Paul Pediatr 2011; 29: 231-238
• 26 Brunet O, Lézini I. Desenvolvimento Psicológico da Primeira Infância. Porto Alegre: Artes Médicas; 1981
• 27 Fily A, Pierrat V, Delporte V, Breart G, Truffert P. ; EPIPAGE Nord-Pas-de-Calais Study Group. Factors associated with neurodevelopmental outcome at 2 years after very preterm birth: the population-based Nord-Pas-de-Calais EPIPAGE cohort. Pediatrics 2006; 117 (02) 357-366
• 28 Flamant C, Branger B, Nguyen The Tich S. , et al. Parent-completed developmental screening in premature children: a valid tool for follow-up programs. PLoS One 2011; 6 (05) e20004
• 29 Gérardin P, Sampériz S, Ramful D. , et al. Neurocognitive outcome of children exposed to perinatal mother-to-child chikungunya virus infection: the CHIMERE cohort study on Reunion Island. PLoS Negl Trop Dis 2014; 8 (07) e2996
• 30 Stoinska B, Gadzinowski J. Neurological and developmental disabilities in ELBW and VLBW: follow-up at 2 years of age. J Perinatol 2011; 31 (02) 137-142
• 31 Nuysink J, van Haastert IC, Eijsermans MJ. , et al. Prediction of gross motor development and independent walking in infants born very preterm using the test of infant motor performance and the Alberta infant motor scale. Early Hum Dev 2013; 89 (09) 693-697
• 32 Wang TN, Howe TH, Hinojosa J, Hsu YW. Postural control of pre-term infants at 6 and 12 months corrected age. Early Hum Dev 2010; 86 (07) 433-437
• 33 Westrup B. Newborn Individualized Developmental Care and Assessment Program (NIDCAP) - family-centered developmentally supportive care. Early Hum Dev 2007; 83 (07) 443-449
• 34 Locatelli A, Andreani M, Pizzardi A, Paterlini G, Stoppa P, Ghidini A. Antenatal variables associated with severe adverse neurodevelopmental outcome among neonates born at less than 32 weeks. Eur J Obstet Gynecol Reprod Biol 2010; 152 (02) 143-147
• 35 Restiffe AP, Gherpelli JL. Differences in walking attainment ages between low-risk preterm and healthy full-term infants. Arq Neuropsiquiatr 2012; 70 (08) 593-598
• 36 Tchamo ME, Prista A, Leandro CG. Low birth weight, very low birth weight and extremely low birth weight in African children aged between 0 and 5 years old: a systematic review. J Dev Orig Health Dis 2016; 7 (04) 408-415
• 37 De Curtis M, Rigo J. The nutrition of preterm infants. Early Hum Dev 2012; 88 (Suppl. 01) S5-S7
• 38 Peterson J, Taylor HG, Minich N, Klein N, Hack M. Subnormal head circumference in very low birth weight children: neonatal correlates and school-age consequences. Early Hum Dev 2006; 82 (05) 325-334
• 39 Fanaro S. Which is the ideal target for preterm growth?. Minerva Pediatr 2010; 62 (03) (Suppl. 01) 77-82
• 40 Wang LY, Wang YL, Wang ST, Huang CC. Using the Alberta infant motor scale to early identify very low-birth-weight infants with cystic periventricular leukomalacia. Brain Dev 2013; 35 (01) 32-37
• 41 Restiffe AP, Gherpelli JL. Comparison of chronological and corrected ages in the gross motor assessment of low-risk preterm infants during the first year of life. Arq Neuropsiquiatr 2006; 64 (2B): 418-425
• 42 Cabral TI, Pereira da Silva LG, Tudella E, Simões Martinez CM. Motor development and sensory processing: a comparative study between preterm and term infants. Res Dev Disabil 2014; 36C: 102-107
• 43 Brown L, Burns YR, Watter P, Gibbons KS, Gray PH. Motor performance, postural stability and behaviour of non-disabled extremely preterm or extremely low birth weight children at four to five years of age. Early Hum Dev 2015; 91 (05) 309-315
• 44 Zwicker JG, Yoon SW, Mackay M, Petrie-Thomas J, Rogers M, Synnes AR. Perinatal and neonatal predictors of developmental coordination disorder in very low birthweight children. Arch Dis Child 2013; 98 (02) 118-122
• 45 Goyen TA, Lui K. Developmental coordination disorder in “apparently normal” schoolchildren born extremely preterm. Arch Dis Child 2009; 94 (04) 298-302