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Synthesis 2018; 50(10): 2119-2123
DOI: 10.1055/s-0036-1591912
DOI: 10.1055/s-0036-1591912
paper
One-Step O-Demethyl-Decarboxylation of ortho-Methoxy Aromatic Carboxylic Acids
We thank the CNRS for its financial support, the Ministère de l’Education Nationale et de la Recherche for a grant to M.P. and M2i company for a grant to E.Z.Further Information
Publication History
Received: 26 December 2017
Accepted: 29 December 2017
Publication Date:
03 April 2018 (online)
Abstract
A highly selective decarboxydemethylation of o-methoxyarenecarboxylic acids is described. The reaction takes place in DMPU at 170 °C in the presence of TMEDA and iron powder. A similar reaction has not been reported until now.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591912.
- Supporting Information
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For selected references on Cu-mediated decarboxylation of aromatic carboxylic acids, see:
For selected references on Ag-, Pd-, and Rh-catalyzed decarboxylation of aromatic carboxylic acids, see:
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