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Synthesis 2018; 50(09): 1907-1913
DOI: 10.1055/s-0036-1591909
DOI: 10.1055/s-0036-1591909
paper
Tin-Powder-Promoted One-Pot Synthesis of 5-Trifluoromethyl-5-aryl-3-methylidenepyrrolidin-2-ones
Authors
We thank the National Natural Science Foundation of China (21462037, 21662030), the Key Laboratory Polymer Materials of Gansu Province (Northwest Normal University), the Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, China, and the State Key Laboratory of Applied Organic Chemistry, Lanzhou University for financial support.
Further Information
Publication History
Received: 08 November 2017
Accepted after revision: 21 December 2017
Publication Date:
29 January 2018 (online)
Abstract
A simple and efficient synthetic approach is reported for the synthesis of 5-trifluoromethyl-5-aryl-3-methylidenepyrrolidin-2-ones in moderate to excellent yields via an acid-catalyzed one-pot multicomponent reaction of aromatic trifluoromethyl ketones, acylhydrazines, and ethyl 2-(bromomethyl)acrylate promoted by tin powder. The protocol is operationally simple. The overall process involves allylation and cyclization of the intermediate of acylhydrazones.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591909.
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