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Synthesis 2018; 50(08): 1721-1727
DOI: 10.1055/s-0036-1591874
DOI: 10.1055/s-0036-1591874
paper
Transition-Metal-Free C–H Arylation of Unactivated Arenes with 8-Hydroxyquinoline as a Promoter
This work was supported by the Natural Science Foundation of China (21402243 and 81602955).Weitere Informationen
Publikationsverlauf
Received: 18. Oktober 2017
Accepted after revision: 30. November 2017
Publikationsdatum:
23. Januar 2018 (online)
Abstract
A method for the transition-metal-free direct C–H arylation of unactivated arenes is developed with aryl bromides as substrates and 8-hydroxyquinoline as an efficient promoter. A variety of biaryl compounds with structural diversity are obtained in moderate to high yields. Mechanistic studies reveal that the reaction proceeds via a homolytic aromatic substitution pathway.
Key words
C–H arylation - metal-free - 8-hydroxyquinoline - biaryl compounds - homolytic aromatic substitutionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591874.
- Supporting Information
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