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Synthesis 2018; 50(06): 1323-1330
DOI: 10.1055/s-0036-1591859
DOI: 10.1055/s-0036-1591859
paper
Reductive N-Arylethylation of Aromatic Amines and N-Heterocycles with Enol Ethers
Weitere Informationen
Publikationsverlauf
Received: 07. Oktober 2017
Accepted after revision: 11. November 2017
Publikationsdatum:
12. Dezember 2017 (online)
Abstract
A convenient method for N-arylethylation of aromatic amines and heterocycles under mild reductive conditions was developed using (2-methoxyvinyl)(hetero)arenes as building blocks and triethylsilane/trifluoroacetic acid as reducing agent. This protocol is compatible with numerous functional groups, and aliphatic amines are inert due to protonation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591859.
- Supporting Information
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