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Synthesis 2018; 50(05): 1090-1096
DOI: 10.1055/s-0036-1591843
paper
© Georg Thieme Verlag Stuttgart · New York

Potassium Carbonate Promoted C–N Coupling Reaction between Benzamides and Aryl Iodides

Fei Huang
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, P. R. of China   Email: zhangsl@suda.edu.cn
,
San Wu
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, P. R. of China   Email: zhangsl@suda.edu.cn
,
Weiye Hu
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, P. R. of China   Email: zhangsl@suda.edu.cn
,
Songlin Zhang*
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University, Suzhou 215123, P. R. of China   Email: zhangsl@suda.edu.cn
› Author AffiliationsWe would like to gratefully acknowledge financial support from the A Project Funded by the Priority Academic Program for the Development of Jiangsu Higher Education Institutions and the National Natural Science Foundation of China (No. 21072143).
Further Information

Publication History

Received: 01 September 2017

Accepted after revision: 03 November 2017

Publication Date:
23 November 2017 (online)

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Abstract

A practical and efficient method for N-arylation of benz­amides promoted by potassium carbonate in the presence of DMEDA was developed. The reaction was carried out without addition of any transition-metal catalyst to afford a variety of N-arylated products in moderate to good yields (up to 97%).

Key words

coupling reaction - potassium carbonate - N-arylation - N-arylbenzamides

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591843. 1H and 13C NMR spectra for all compounds are included.
  • Supporting Information
 

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