We report a method for synthesizing optically active 2,3-disubstituted indolines by
the cycloaddition reaction of benzynes with various 4-[(4-toluenesulfonyl)amino]-(E)-but-2-enenitriles, which are readily prepared from the corresponding l-amino acid derivatives.
Keywords
indolines - benzynes - cycloaddition - asymmetric synthesis - nucleophilic addition
- amino acids