Copper-Catalyzed S-Arylation of Arylthioureas by Using Diaryl­iodonium Salts

Abstract

A convenient and efficient copper-catalyzed S-arylation of arylthioureas using diaryliodonium salts is reported. The desired arylisothioureas were synthesized in good yields in the presence of CuCl as catalyst and K₂CO₃ as base, and a wide variety of functional groups on the arylthioureas and diaryliodonium salts were tolerated. The protocol affords an alternative synthesis of some potentially useful biological and pharmaceutical compounds.

Key words

copper - S-arylation - arylthioureas - diaryliodonium salts - synthesis

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