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Synthesis 2017; 49(11): 2461-2469
DOI: 10.1055/s-0036-1588968
DOI: 10.1055/s-0036-1588968
paper
Electrophilic Trapping of Zirconium Enolates Obtained by Copper-Catalyzed Addition of In Situ Generated Organozirconium Reagents
Further Information
Publication History
Received: 01 February 2017
Accepted after revision: 17 February 2017
Publication Date:
10 March 2017 (online)
Abstract
Building complex structures from simple starting materials is important for effective organic synthesis. In this context, domino reactions comprising hydrozirconation of alkenes, their subsequent utilization in a copper-catalyzed conjugate addition to enones, followed by electrophilic trapping of the formed zirconium enolates with activated alkene and carbocations are described. Reactivity of metal enolates was studied by DFT calculations.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588968.
- Supporting Information
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