Synlett 2017; 28(08): 944-950
DOI: 10.1055/s-0036-1588944
letter
© Georg Thieme Verlag Stuttgart · New York

Total Syntheses of Atrovenetin and Atrovenetinone: A Naphthalene-Annulation Approach to a Discoid Tricycle Using Allenic Acid

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Publikationsverlauf

Received: 12. Dezember 2016

Accepted after revision: 09. Januar 2017

Publikationsdatum:
06. Februar 2017 (online)


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Abstract

A total synthesis of atrovenetin has been achieved. The discoid tricyclic motif was constructed by a novel three-carbon annulation of naphthalene derivative and allenic acid under acidic conditions. An effective protocol for the conversion of atrovenetin into atrovenetinone has been established.

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