Tandem and One-Pot Hydroformylation/Michael Reactions of Acrylates

In memory of Professor Marta Sališová, who dedicated her life to raise and motivate young scientists

Abstract

The combination of various reactions in one operational step leads to many advantages in synthetic strategies, such as a lower consumption of resources, effort, and time, when intermittent workup and purification steps can be avoided. The hydroformylation reaction of acrylates gives access to 2-formylpropanoates, which thanks to their structural features constitute useful intermediates in the synthesis of more complex compounds. Herein, we report a simple and convenient one-pot strategy to synthesize functionalized carbonyl compounds starting from these readily available substrates, via tandem or one-pot hydroformylation, Michael addition, and aldol reactions.

Key words

hydroformylation - acrylates - rhodium - one pot - tandem - Michael addition

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