A Short and Improved Synthesis of the Antiprotozoal Abietane Diterpenoid (–)-Sugikurojin A

Miguel A. González-Cardenete; Ramón J. Zaragozá

doi:10.1055/s-0036-1588353

Synthesis, Inhaltsverzeichnis

Synthesis 2017; 49(06): 1315-1318
DOI: 10.1055/s-0036-1588353

paper

A Short and Improved Synthesis of the Antiprotozoal Abietane Diterpenoid (–)-Sugikurojin A

Miguel A. González-Cardenete*

^aInstituto de Tecnología Química (UPV-CSIC), Universitat Politècnica de Valencia-Consejo Superior de Investigaciones Científicas, Avda de los Naranjos s/n, 46022 Valencia, Spain eMail: migoncar@itq.upv.es

,

Ramón J. Zaragozá*

^bDepartamento de Química Orgánica, Universidad de Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain eMail: Ramon.J.Zaragoza@uv.es

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Abstract

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Abstract

An efficient and straightforward semisynthesis of the antiprotozoal abietane diterpenoid (–)-sugikurojin A, starting from the readily available methyl ester of callitrisic acid (4-epi-dehydroabietic acid) isolated from sandarac resin, is reported. This optimized semisynthetic route provides a convenient source of the antiprotozoal compound, in four steps from methyl callitrisate in 50% overall yield, for further biological studies.

Key words

terpenoids - abietanes - semisynthesis - acylation - callitrisic acid

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Referenzen

References
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