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Synthesis 2017; 49(06): 1315-1318
DOI: 10.1055/s-0036-1588353
DOI: 10.1055/s-0036-1588353
paper
A Short and Improved Synthesis of the Antiprotozoal Abietane Diterpenoid (–)-Sugikurojin A
Further Information
Publication History
Received: 05 September 2016
Accepted after revision: 24 October 2016
Publication Date:
28 November 2016 (online)
Abstract
An efficient and straightforward semisynthesis of the antiprotozoal abietane diterpenoid (–)-sugikurojin A, starting from the readily available methyl ester of callitrisic acid (4-epi-dehydroabietic acid) isolated from sandarac resin, is reported. This optimized semisynthetic route provides a convenient source of the antiprotozoal compound, in four steps from methyl callitrisate in 50% overall yield, for further biological studies.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588353.
- Supporting Information
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