Chiral Gold Complex Catalyzed Tandem Dehydrative Cyclization/Hetero-Diels–Alder Reaction

Yu-Liu Du; Feng Zhao; Zhi-Yong Han; Liu-Zhu Gong

doi:10.1055/s-0036-1588305

Synthesis, Table of Contents

Synthesis 2017; 49(01): 151-158
DOI: 10.1055/s-0036-1588305

paper

Chiral Gold Complex Catalyzed Tandem Dehydrative Cyclization/Hetero-Diels–Alder Reaction

Yu-Liu Du

Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China Email: gonglz@ustc.edu.cn

,

Feng Zhao

Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China Email: gonglz@ustc.edu.cn

,

Zhi-Yong Han

Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China Email: gonglz@ustc.edu.cn

,

Liu-Zhu Gong*

Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China Email: gonglz@ustc.edu.cn

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Abstract

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Abstract

A tandem dehydrative cyclization/aza-hetero-Diels–Alder reaction catalyzed by gold(I) complex bearing BINOL-derived chiral phosphoramidite ligand has been developed. With this method, optically active chiral bicyclic tetrahydropyridazine derivatives could be obtained in one step from readily available starting materials.

Key words

asymmetric gold catalysis - tandem reaction - hetero-Diels–Alder reaction

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References

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