Synthesis 2017; 49(03): 604-614
DOI: 10.1055/s-0036-1588299
paper
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

Kadri Kriis
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
,
Triin Melnik
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
,
Kristiina Lips
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
,
Ilona Juhanson
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
,
Sandra Kaabel
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
,
Ivar Järving
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
,
Tõnis Kanger*
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia   Email: tonis.kanger@ttu.ee
› Author Affiliations
Further Information

Publication History

Received: 28 June 2016

Accepted after revision: 01 August 2016

Publication Date:
02 September 2016 (online)


Abstract

Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

Supporting Information

 
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