Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Abstract

The total synthesis of biselide A based on our earlier strategy of synthesizing haterumalides is reported. The highlights of this approach are the use of regioselective enzymatic hydrolysis for the installation of a C20 oxygen functional group and an asymmetric aldol reaction for the stereoselective introduction of a C3 oxygen functional group.

Key words

biselide A - haterumalides - macrolide - regioselective enzymatic hydrolysis - asymmetric aldol reaction

• References

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