Synthesis, Table of Contents

Synthesis 2017; 49(06): 1335-1341
DOI: 10.1055/s-0036-1588101

paper

© Georg Thieme Verlag Stuttgart · New York

One-Pot Synthesis of Imidazolyl Isoquinolines under a Palladium-Catalyzed C–H Activation/Annulation (CHAA) Reaction

Ranran Zhu

^aSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China

^bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China

^cTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China Email: jhuang@tju.edu.cn

,

Yuntao Wang

^aSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China

^bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China

^cTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China Email: jhuang@tju.edu.cn

,

Jialin Liu

^aSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China

^bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China

^cTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China Email: jhuang@tju.edu.cn

,

Qing Wang

^aSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China

^bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China

^cTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China Email: jhuang@tju.edu.cn

,

Jianhui Huang*

^aSchool of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. of China

^bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China

^cTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China Email: jhuang@tju.edu.cn

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Abstract

A microwave-assisted Pd-catalyzed one-pot C–H activation/annulation (CHAA) protocol has been developed for the synthesis of imidazo[2,1-a]isoquinolines and benzo[4,5]imidazo[2,1-a]isoquinolines. Further N-alkylation for the preparation of a series of the corresponding isoquinolium salts has also been demonstrated. The fluorescent properties of these isoquinolines have been studied.

Key words

Key words

C–H activation/annulation - microwave - fluorophore - heterocycle - fluorescent

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Supplementary Material

Supplementary Material

Supporting Information