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Synthesis 2017; 49(11): 2488-2494
DOI: 10.1055/s-0036-1558963
DOI: 10.1055/s-0036-1558963
paper
Three-Component One-Pot Reactions of 2-Trifluoromethyl-N-nosylaziridine, Primary Amines, and Vinylsulfonium Salts for Convenient Access to CF3-Containing Piperazines
Further Information
Publication History
Received: 06 February 2017
Accepted after revision: 13 February 2017
Publication Date:
02 March 2017 (online)
Abstract
Trifluoromethylated piperazines were readily synthesized with excellent regioselectivity in high yields by the sequential reaction of 2-trifluoromethylated N-nosylaziridine (2-CF3-N-Ns-aziridine) with various primary amines, followed by treatment with vinylsulfonium salts, in one pot.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1558963.
- Supporting Information
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