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Synthesis 2016; 48(19): 3413-3419
DOI: 10.1055/s-0035-1562785
DOI: 10.1055/s-0035-1562785
paper
Highly Diastereoselective and Irreversible Aldol Reactions of N-Sulfonylimidates
Further Information
Publication History
Received: 26 May 2016
Accepted after revision: 29 June 2016
Publication Date:
30 August 2016 (online)
Dedicated to the memory of Prof. Jean Normant, an exceptional and inspiring supervisor
Abstract
A mild method for the aldolization of N-sulfonylimidates was developed. The reaction proceeds in excellent diastereoselectivity to provide a range of useful β-hydroxyimidates in high yield. The innate reversibility of the reaction is suppressed by the use of a titanium complex as a Lewis acid.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562785.
- Supporting Information
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