Synfacts 2016; 12(09): 0911
DOI: 10.1055/s-0035-1562556
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Molecular Knot Inducing Allosteric Control of Catalysis

Timothy M. Swager
Constantin-Christian A. Voll
Marcos V, Stephens AJ, Jaramillo-Garcia J, Nussbaumer AL, Woltering SL, Valero A, Lemonnier J.-F, Vitorica-Yrezabal IJ, Leigh DA * University of Manchester, UK
Allosteric Initiation and Regulation of Catalysis with a Molecular Knot.

Science 2016;
352: 1555-1559
Further Information

Publication History

Publication Date:
18 August 2016 (online)



Molecular knots are found in nature and, although synthetic knots have been synthesized, the benefits of knotted molecules remain unclear. In this report, the authors synthesize a molecular knot, perform a metal exchange, and are able to establish a catalytic cycle that can be allosterically initiated and regulated.



The synthesis of the molecular knot is high yielding and both removal of metals and exchange is possible without uncoiling of the structure. The authors show catalytic hydrolysis, ­Michael addition, and Diels–Alder reactions.