Green NJ, Willis AC, Sherburn MS * Australian National University, Canberra, Australia
Direct Cross-Couplings of Propargylic Diols.
Angew. Chem. Int. Ed. 2016;
55: 9244-9248
Key words
propargyl diols - boron - Suzuki–Miyaura coupling
Significance
The authors report a step-economical and functional group tolerant method for the synthesis of tetra-, penta-, and hexa-substituted 1,3-butadienes from underivatized propargylic diols and aryl or alkenyl boronic acids in moderate to high yields.
Comment
The reported method can be applied to remarkably short syntheses of highly substituted benzofulvenes and aryl indenes through treatment of the cross-coupled products with acid.
