Direct Cross-Couplings of Propargylic Diols

Paul Knochel; Marthe Ketels

doi:10.1055/s-0035-1561874

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml

Teilen / Bookmarken

Facebook Linkedin Weibo

PDF herunterladen

Synfacts 2016; 12(09): 0955
DOI: 10.1055/s-0035-1561874

Metal-Mediated Synthesis

Direct Cross-Couplings of Propargylic Diols

Rezensent(en):

Paul Knochel

,

Marthe Ketels

Green NJ, Willis AC, Sherburn MS * Australian National University, Canberra, Australia
Direct Cross-Couplings of Propargylic Diols.

Angew. Chem. Int. Ed. 2016;
55: 9244-9248

Crossref PubMed Suche in Google Scholar

Weitere Informationen

Publikationsverlauf

Publikationsdatum:
18. August 2016 (online)

Abstract
Volltext
Abbildungen

als PDF herunterladen Lizenzen und Reprints

Key words

propargyl diols - boron - Suzuki–Miyaura coupling

Significance

The authors report a step-economical and functional group tolerant method for the synthesis of tetra-, penta-, and hexa-substituted 1,3-butadienes from underivatized propargylic diols and aryl or alkenyl boronic acids in moderate to high yields.

Comment

The reported method can be applied to remarkably short syntheses of highly substituted benzofulvenes and aryl indenes through treatment of the cross-coupled products with acid.

Lizenzen und Reprints