The Total Synthesis of Hyperforin

Abstract

Hyperforin has remained a popular and challenging synthetic target since its isolation over forty years ago. As a result, numerous synthetic strategies and ring-forming reactions have been developed to address its formidable molecular architecture. Herein we describe our contributions to this area resulting in a ten-step synthetic pathway enabled by a novel diketene annulation reaction and oxidative ring expansion strategy.

Key words

meroterpene - hypervalent iodine - ring expansion - total synthesis - natural products - annulation

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