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Synthesis 2016; 48(13): 2112-2120
DOI: 10.1055/s-0035-1561593
DOI: 10.1055/s-0035-1561593
paper
Regioselective Michael Addition of Anthrone to Methyleneindolinones
Further Information
Publication History
Received: 10 December 2015
Accepted after revision: 04 March 2016
Publication Date:
18 April 2016 (online)
Abstract
Regioselective Michael addition of anthrone to methyleneindolinones catalyzed by Et3N was developed. The reaction furnished structurally interesting hybrid derivatives of oxindoles and anthrones in high yield, high regioselectivity, and high diastereoselectivity. Electronic effects had a dramatic influence on both the regioselectivity and diastereoselectivity, which could be finely tuned by changing the substituents on the methyleneindolinones.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561593.
- Supporting Information
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