Synthesis 2016; 48(19): 3272-3278
DOI: 10.1055/s-0035-1561484
paper
© Georg Thieme Verlag Stuttgart · New York

Continuous Flow Synthesis of Dimethylalkynylaluminum Reagents

Riccardo Piccardi*
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS-Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France   Email: riccardo.piccardi@parisdescartes.fr   Email: laurent.micouin@parisdescartes.fr
,
Anais Coffinet
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS-Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France   Email: riccardo.piccardi@parisdescartes.fr   Email: laurent.micouin@parisdescartes.fr
,
Erica Benedetti
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS-Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France   Email: riccardo.piccardi@parisdescartes.fr   Email: laurent.micouin@parisdescartes.fr
,
Serge Turcaud
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS-Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France   Email: riccardo.piccardi@parisdescartes.fr   Email: laurent.micouin@parisdescartes.fr
,
Laurent Micouin*
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS-Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France   Email: riccardo.piccardi@parisdescartes.fr   Email: laurent.micouin@parisdescartes.fr
› Author Affiliations
Further Information

Publication History

Received: 12 May 2016

Accepted after revision: 08 June 2016

Publication Date:
07 July 2016 (online)


In memory of Prof. Jean Normant

Abstract

A new process for the synthesis of dimethylalkynylaluminum reagents under flow conditions is described. It involves a base-catalyzed alumination of terminal alkynes using a resin-supported organocatalyst. Final organometallic species are obtained in solution, and can further react with various aldehydes or nitrones.

Supporting Information

 
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